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Dokumenttyp:
journal article 
Autor(en):
Weidinger, S; Gieger, C; Rodriguez, E; Baurecht, H; Mempel, M; Klopp, N; Gohlke, H; Wagenpfeil, S; Ollert, M; Ring, J; Behrendt, H; Heinrich, J; Novak, N; Bieber, T; Krämer, U; Berdel, D; von Berg, A; Bauer, CP; Herbarth, O; Koletzko, S; Prokisch, H; Mehta, D; Meitinger, T; Depner, M; von Mutius, E; Liang, L; Moffatt, M; Cookson, W; Kabesch, M; Wichmann, HE; Illig, T 
Titel:
Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus. 
Abstract:
High levels of serum IgE are considered markers of parasite and helminth exposure. In addition, they are associated with allergic disorders, play a key role in anti-tumoral defence, and are crucial mediators of autoimmune diseases. Total IgE is a strongly heritable trait. In a genome-wide association study (GWAS), we tested 353,569 SNPs for association with serum IgE levels in 1,530 individuals from the population-based KORA S3/F3 study. Replication was performed in four independent population-b...    »
 
Zeitschriftentitel:
PLoS Genet 
Jahr:
2008 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
e1000166 
Sprache:
eng 
Print-ISSN:
1553-7390 
TUM Einrichtung:
r Dermatologie und Allergologie; r Medizinische Statistik und Epidemiologie; Kinderklinik und Poliklinik; r Humangenetik