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Document type:
journal article 
Author(s):
Müller-Hermelink, N; Braumüller, H; Pichler, B; Wieder, T; Mailhammer, R; Schaak, K; Ghoreschi, K; Yazdi, A; Haubner, R; Sander, CA; Mocikat, R; Schwaiger, M; Förster, I; Huss, R; Weber, WA; Kneilling, M; Röcken, M 
Title:
TNFR1 signaling and IFN-gamma signaling determine whether T cells induce tumor dormancy or promote multistage carcinogenesis. 
Abstract:
Immune responses may arrest tumor growth by inducing tumor dormancy. The mechanisms leading to either tumor dormancy or promotion of multistage carcinogenesis by adaptive immunity are poorly characterized. Analyzing T antigen (Tag)-induced multistage carcinogenesis in pancreatic islets, we show that Tag-specific CD4+ T cells home selectively into the tumor microenvironment around the islets, where they either arrest or promote transition of dysplastic islets into islet carcinomas. Through combin...    »
 
Journal title abbreviation:
Cancer Cell 
Year:
2008 
Journal volume:
13 
Journal issue:
Pages contribution:
507-18 
Language:
eng 
Print-ISSN:
1535-6108 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik