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Document type:
journal article 
Author(s):
Willhauck, MJ; Sharif-Samani, B; Senekowitsch-Schmidtke, R; Wunderlich, N; Göke, B; Morris, JC; Spitzweg, C 
Title:
Functional sodium iodide symporter expression in breast cancer xenografts in vivo after systemic treatment with retinoic acid and dexamethasone. 
Abstract:
CONTEXT: The sodium iodide symporter (NIS) mediates iodide uptake in the thyroid gland as well as in lactating breast, and is also expressed in the majority of breast cancers. Recently, we have reported stimulation of all-trans retinoic acid (atRA)-induced NIS expression in the human breast cancer cell line MCF-7 by dexamethasone (Dex), resulting in an enhanced therapeutic effect of (131)I in vitro. OBJECTIVE: In the current study we examined the efficacy of Dex stimulation of atRA-induced NIS e...    »
 
Journal title abbreviation:
Breast Cancer Res Treat 
Year:
2008 
Journal volume:
109 
Journal issue:
Pages contribution:
263-72 
Language:
eng 
Print-ISSN:
0167-6806 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik