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Document type:
journal article 
Author(s):
Willhauck, MJ; Samani, BR; Wolf, I; Senekowitsch-Schmidtke, R; Stark, HJ; Meyer, GJ; Knapp, WH; Göke, B; Morris, JC; Spitzweg, C 
Title:
The potential of 211Astatine for NIS-mediated radionuclide therapy in prostate cancer. 
Abstract:
PURPOSE: We reported recently the induction of selective iodide uptake in prostate cancer cells (LNCaP) by prostate-specific antigen (PSA) promoter-directed sodium iodide symporter (NIS) expression that allowed a significant therapeutic effect of (131)I. In the current study, we studied the potential of the high-energy alpha-emitter (211)At, also transported by NIS, as an alternative radionuclide after NIS gene transfer in tumors with limited therapeutic efficacy of (131)I due to rapid iodide ef...    »
 
Journal title abbreviation:
Eur J Nucl Med Mol Imaging 
Year:
2008 
Journal volume:
35 
Journal issue:
Pages contribution:
1272-81 
Language:
eng 
Print-ISSN:
1619-7070 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik