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Dokumenttyp:
journal article 
Autor(en):
Morgenroth, A; Deisenhofer, S; Neininger, M; Vogg, AT; Glatting, G; Kull, T; Reske, SN 
Titel:
Biodistribution, cellular uptake and DNA-incorporation of the 2'-fluoro stabilized 5-iodo-2'-deoxyuridine analog 5-iodo-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil (FIAU). 
Abstract:
AIM: 5-Iodo-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) uracil (FIAU) has been used for non-invasive monitoring of gene therapy and as an antiviral agent experimentally and in patients. However, FIAU metabolism in tumor cells is largely unknown. Here, the biological characteristics of FIAU in human leukemia and lymphoma cells in vitro and in a xenotransplant severe combined immunodeficient (SCID)-mouse model were investigated. METHODS: The susceptibility of FIAU to glycosidic bond cleavage by thy...    »
 
Zeitschriftentitel:
Q J Nucl Med Mol Imaging 
Jahr:
2008 
Band / Volume:
52 
Heft / Issue:
Seitenangaben Beitrag:
305-16 
Sprache:
eng 
Print-ISSN:
1824-4785 
TUM Einrichtung:
Nuklearmedizinische Klinik und Poliklinik