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Document type:
journal article 
Author(s):
Morgenroth, A; Deisenhofer, S; Neininger, M; Vogg, AT; Glatting, G; Kull, T; Reske, SN 
Title:
Biodistribution, cellular uptake and DNA-incorporation of the 2'-fluoro stabilized 5-iodo-2'-deoxyuridine analog 5-iodo-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil (FIAU). 
Abstract:
AIM: 5-Iodo-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) uracil (FIAU) has been used for non-invasive monitoring of gene therapy and as an antiviral agent experimentally and in patients. However, FIAU metabolism in tumor cells is largely unknown. Here, the biological characteristics of FIAU in human leukemia and lymphoma cells in vitro and in a xenotransplant severe combined immunodeficient (SCID)-mouse model were investigated. METHODS: The susceptibility of FIAU to glycosidic bond cleavage by thy...    »
 
Journal title abbreviation:
Q J Nucl Med Mol Imaging 
Year:
2008 
Journal volume:
52 
Journal issue:
Pages contribution:
305-16 
Language:
eng 
Print-ISSN:
1824-4785 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik