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Document type:
journal article 
Author(s):
Henriksen, G; Yousefi, BH; Drzezga, A; Wester, HJ 
Title:
Development and evaluation of compounds for imaging of beta-amyloid plaque by means of positron emission tomography. 
Abstract:
PURPOSE: The proof of concept for in vivo targeting of beta-amyloid plaques (Abeta) in patients with Alzheimer's disease (AD) by means of nuclear imaging methods has been shown in recent clinical studies. METHODS: For positron emission tomography (PET), the five compounds [(11)C]PIB, 3'[(18)F]FPIB, [(18)F]FDDNP, [(11)C]SB-13 and [(18)F]F-SB-13 have been developed by a formal charge neutralisation of agents used for staining of AD brain post mortem. RESULTS: In AD-patients, these compounds have b...    »
 
Journal title abbreviation:
Eur J Nucl Med Mol Imaging 
Year:
2008 
Journal volume:
35 Suppl 1 
Pages contribution:
S75-81 
Language:
eng 
Print-ISSN:
1619-7070 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik