Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Decristoforo, C; Hernandez Gonzalez, I; Carlsen, J; Rupprich, M; Huisman, M; Virgolini, I; Wester, HJ; Haubner, R 
Titel:
68Ga- and 111In-labelled DOTA-RGD peptides for imaging of alphavbeta3 integrin expression. 
Abstract:
PURPOSE: alphavbeta3 integrins are important cell adhesion receptors involved in angiogenic processes. Recently, we demonstrated using [(18)F]Galacto-RGD that monitoring of alphavbeta3 expression is feasible. Here, we introduce (68)Ga- and (111)In-labelled derivatives and compare them with [(18)F]Galacto-RGD. METHODS: For radiolabelling, cyclo(RGDfK(DOTA)) was synthesised using SPPS. For in vitro characterisation determination of partition coefficients, protein binding, metabolic stability, alph...    »
 
Zeitschriftentitel:
Eur J Nucl Med Mol Imaging 
Jahr:
2008 
Band / Volume:
35 
Heft / Issue:
Seitenangaben Beitrag:
1507-15 
Sprache:
eng 
Print-ISSN:
1619-7070 
TUM Einrichtung:
Nuklearmedizinische Klinik und Poliklinik