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Document type:
journal article 
Author(s):
Decristoforo, C; Hernandez Gonzalez, I; Carlsen, J; Rupprich, M; Huisman, M; Virgolini, I; Wester, HJ; Haubner, R 
Title:
68Ga- and 111In-labelled DOTA-RGD peptides for imaging of alphavbeta3 integrin expression. 
Abstract:
PURPOSE: alphavbeta3 integrins are important cell adhesion receptors involved in angiogenic processes. Recently, we demonstrated using [(18)F]Galacto-RGD that monitoring of alphavbeta3 expression is feasible. Here, we introduce (68)Ga- and (111)In-labelled derivatives and compare them with [(18)F]Galacto-RGD. METHODS: For radiolabelling, cyclo(RGDfK(DOTA)) was synthesised using SPPS. For in vitro characterisation determination of partition coefficients, protein binding, metabolic stability, alph...    »
 
Journal title abbreviation:
Eur J Nucl Med Mol Imaging 
Year:
2008 
Journal volume:
35 
Journal issue:
Pages contribution:
1507-15 
Language:
eng 
Print-ISSN:
1619-7070 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik