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Dokumenttyp:
journal article 
Autor(en):
Schottelius, M; Berger, S; Poethko, T; Schwaiger, M; Wester, HJ 
Titel:
Development of novel 68Ga- and 18F-labeled GnRH-I analogues with high GnRHR-targeting efficiency. 
Abstract:
A large majority of tumors of the reproductive system express the gonadotropin releasing hormone receptor (GnRHR). Blockade and activation of this receptor with various antagonistic and agonistic analogues of native GnRH-I (pGlu(1)-His(2)-Trp(3)-Ser(4)-Tyr(5)-Gly (6)-Leu(7)-Arg(8)-Pro(9)-Gly(10)-NH2), respectively, has shown efficient suppression of tumor growth. In this study, the GnRH-receptor system has been evaluated with respect to its suitability as a target for in vivo peptide receptor ta...    »
 
Zeitschriftentitel:
Bioconjug Chem 
Jahr:
2008 
Band / Volume:
19 
Heft / Issue:
Seitenangaben Beitrag:
1256-68 
Sprache:
eng 
Print-ISSN:
1043-1802 
TUM Einrichtung:
Nuklearmedizinische Klinik und Poliklinik