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Document type:
journal article 
Author(s):
Schottelius, M; Berger, S; Poethko, T; Schwaiger, M; Wester, HJ 
Title:
Development of novel 68Ga- and 18F-labeled GnRH-I analogues with high GnRHR-targeting efficiency. 
Abstract:
A large majority of tumors of the reproductive system express the gonadotropin releasing hormone receptor (GnRHR). Blockade and activation of this receptor with various antagonistic and agonistic analogues of native GnRH-I (pGlu(1)-His(2)-Trp(3)-Ser(4)-Tyr(5)-Gly (6)-Leu(7)-Arg(8)-Pro(9)-Gly(10)-NH2), respectively, has shown efficient suppression of tumor growth. In this study, the GnRH-receptor system has been evaluated with respect to its suitability as a target for in vivo peptide receptor ta...    »
 
Journal title abbreviation:
Bioconjug Chem 
Year:
2008 
Journal volume:
19 
Journal issue:
Pages contribution:
1256-68 
Language:
eng 
Print-ISSN:
1043-1802 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik