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Document type:
journal article 
Author(s):
Gross, O; Grupp, C; Steinberg, C; Zimmermann, S; Strasser, D; Hannesschläger, N; Reindl, W; Jonsson, H; Huo, H; Littman, DR; Peschel, C; Yokoyama, WM; Krug, A; Ruland, J 
Title:
Multiple ITAM-coupled NK-cell receptors engage the Bcl10/Malt1 complex via Carma1 for NF-kappaB and MAPK activation to selectively control cytokine production. 
Abstract:
Natural killer (NK) cells are innate immune cells that mediate resistance against viruses and tumors. They express multiple activating receptors that couple to immunoreceptor tyrosine-based activation motif (ITAM)-containing signaling chains for downstream cell activation. Ligation of activating NK-cell receptors induces NK-cell cytotoxicity and cytokine release. How these distinct events are selectively controlled is not well defined. Here we report the identification of a specific signaling pa...    »
 
Journal title abbreviation:
Blood 
Year:
2008 
Journal volume:
112 
Journal issue:
Pages contribution:
2421-8 
Language:
eng 
Print-ISSN:
0006-4971 
TUM Institution:
III. Medizinische Klinik und Poliklinik