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Document type:
journal article 
Author(s):
Kancha, RK; von Bubnoff, N; Miething, C; Peschel, C; Götze, KS; Duyster, J 
Title:
Imatinib and leptomycin B are effective in overcoming imatinib-resistance due to Bcr-Abl amplification and clonal evolution but not due to Bcr-Abl kinase domain mutation. 
Abstract:
Treatment with imatinib is very effective in Bcr-Abl positive leukemia. However, development of resistance to this drug is a common phenomenon in late stage disease. The Bcr-Abl protein localizes to the cytoplasm in transformed cells but can enter the nucleus upon treatment with imatinib. Using leptomycin B, a nuclear export blocker, it has been shown that reactivated nuclear Bcr-Abl kinase activity can induce cell death, thus presenting an interesting potential treatment option for imatinib res...    »
 
Journal title abbreviation:
Haematologica 
Year:
2008 
Journal volume:
93 
Journal issue:
11 
Pages contribution:
1718-22 
Language:
eng 
Print-ISSN:
0390-6078 
TUM Institution:
III. Medizinische Klinik und Poliklinik