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Dokumenttyp:
journal article 
Autor(en):
Lössner, D; Abou-Ajram, C; Benge, A; Reuning, U 
Titel:
Integrin alphavbeta3 mediates upregulation of epidermal growth-factor receptor expression and activity in human ovarian cancer cells. 
Abstract:
Upon overexpression of integrin alphavbeta3 and its engagement by vitronectin, we previously showed enhanced adhesion, proliferation, and motility of human ovarian cancer cells. By studying differential expression of genes possibly related to these tumor biological events, we identified the epidermal growth-factor receptor (EGF-R) to be under control of alphavbeta3 expression levels. Thus in the present study we characterized alphavbeta3-dependent changes of EGF-R and found significant upregulat...    »
 
Zeitschriftentitel:
Int J Biochem Cell Biol 
Jahr:
2008 
Band / Volume:
40 
Heft / Issue:
12 
Seitenangaben Beitrag:
2746-61 
Sprache:
eng 
Print-ISSN:
1357-2725 
TUM Einrichtung:
Frauenklinik und Poliklinik