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Document type:
journal article 
Author(s):
Lössner, D; Abou-Ajram, C; Benge, A; Reuning, U 
Title:
Integrin alphavbeta3 mediates upregulation of epidermal growth-factor receptor expression and activity in human ovarian cancer cells. 
Abstract:
Upon overexpression of integrin alphavbeta3 and its engagement by vitronectin, we previously showed enhanced adhesion, proliferation, and motility of human ovarian cancer cells. By studying differential expression of genes possibly related to these tumor biological events, we identified the epidermal growth-factor receptor (EGF-R) to be under control of alphavbeta3 expression levels. Thus in the present study we characterized alphavbeta3-dependent changes of EGF-R and found significant upregulat...    »
 
Journal title abbreviation:
Int J Biochem Cell Biol 
Year:
2008 
Journal volume:
40 
Journal issue:
12 
Pages contribution:
2746-61 
Language:
eng 
Print-ISSN:
1357-2725 
TUM Institution:
Frauenklinik und Poliklinik