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Dokumenttyp:
journal article 
Autor(en):
Osorio, A; Pollán, M; Pita, G; Schmutzler, RK; Versmold, B; Engel, C; Meindl, A; Arnold, N; Preisler-Adams, S; Niederacher, D; Hofmann, W; Gadzicki, D; Jakubowska, A; Hamann, U; Lubinski, J; Toloczko-Grabarek, A; Cybulski, C; Debniak, T; Llort, G; Yannoukakos, D; Díez, O; Peissel, B; Peterlongo, P; Radice, P; Heikkinen, T; Nevanlinna, H; Mai, PL; Loud, JT; McGuffog, L; Antoniou, AC; Benitez, J; CIMBA 
Titel:
An evaluation of the polymorphisms Ins16bp and Arg72Pro in p53 as breast cancer risk modifiers in BRCA1 and BRCA2 mutation carriers. 
Abstract:
The close functional relationship between p53 and the breast cancer susceptibility genes BRCA1 and BRCA2 has promoted the investigation of various polymorphisms in the p53 gene as possible risk modifiers in BRCA1/2 mutation carriers. Specifically, two polymorphisms in p53, c.97-147ins16bp and p.Arg72Pro have been analysed as putative breast cancer susceptibility variants, and it has been recently reported that a p53 haplotype combining the absence of the 16-bp insertion and the presence of proli...    »
 
Zeitschriftentitel:
Br J Cancer 
Jahr:
2008 
Band / Volume:
99 
Heft / Issue:
Seitenangaben Beitrag:
974-7 
Sprache:
eng 
Print-ISSN:
0007-0920 
TUM Einrichtung:
Frauenklinik und Poliklinik