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Document type:
journal article 
Author(s):
Osorio, A; Pollán, M; Pita, G; Schmutzler, RK; Versmold, B; Engel, C; Meindl, A; Arnold, N; Preisler-Adams, S; Niederacher, D; Hofmann, W; Gadzicki, D; Jakubowska, A; Hamann, U; Lubinski, J; Toloczko-Grabarek, A; Cybulski, C; Debniak, T; Llort, G; Yannoukakos, D; Díez, O; Peissel, B; Peterlongo, P; Radice, P; Heikkinen, T; Nevanlinna, H; Mai, PL; Loud, JT; McGuffog, L; Antoniou, AC; Benitez, J; CIMBA 
Title:
An evaluation of the polymorphisms Ins16bp and Arg72Pro in p53 as breast cancer risk modifiers in BRCA1 and BRCA2 mutation carriers. 
Abstract:
The close functional relationship between p53 and the breast cancer susceptibility genes BRCA1 and BRCA2 has promoted the investigation of various polymorphisms in the p53 gene as possible risk modifiers in BRCA1/2 mutation carriers. Specifically, two polymorphisms in p53, c.97-147ins16bp and p.Arg72Pro have been analysed as putative breast cancer susceptibility variants, and it has been recently reported that a p53 haplotype combining the absence of the 16-bp insertion and the presence of proli...    »
 
Journal title abbreviation:
Br J Cancer 
Year:
2008 
Journal volume:
99 
Journal issue:
Pages contribution:
974-7 
Language:
eng 
Print-ISSN:
0007-0920 
TUM Institution:
Frauenklinik und Poliklinik