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Dokumenttyp:
journal article 
Autor(en):
Yang, R; Frank, B; Hemminki, K; Bartram, CR; Wappenschmidt, B; Sutter, C; Kiechle, M; Bugert, P; Schmutzler, RK; Arnold, N; Weber, BH; Niederacher, D; Meindl, A; Burwinkel, B 
Titel:
SNPs in ultraconserved elements and familial breast cancer risk. 
Abstract:
Ultraconserved elements (UCEs) are segments of>200 bp length showing absolute sequence identity between orthologous regions of human, rat and mouse genomes. The selection factors acting on these UCEs are still unknown. Recent studies have shown that UCEs function as long-range enhancers of flanking genes or are involved in splicing when overlapping with exons. The depletion of UCEs among copy number variation as well as the significant under-representation of single-nucleotide polymorphisms (SNP...    »
 
Zeitschriftentitel:
Carcinogenesis 
Jahr:
2008 
Band / Volume:
29 
Heft / Issue:
Seitenangaben Beitrag:
351-5 
Sprache:
eng 
Print-ISSN:
0143-3334 
TUM Einrichtung:
Frauenklinik und Poliklinik