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Document type:
journal article 
Author(s):
Yang, R; Frank, B; Hemminki, K; Bartram, CR; Wappenschmidt, B; Sutter, C; Kiechle, M; Bugert, P; Schmutzler, RK; Arnold, N; Weber, BH; Niederacher, D; Meindl, A; Burwinkel, B 
Title:
SNPs in ultraconserved elements and familial breast cancer risk. 
Abstract:
Ultraconserved elements (UCEs) are segments of>200 bp length showing absolute sequence identity between orthologous regions of human, rat and mouse genomes. The selection factors acting on these UCEs are still unknown. Recent studies have shown that UCEs function as long-range enhancers of flanking genes or are involved in splicing when overlapping with exons. The depletion of UCEs among copy number variation as well as the significant under-representation of single-nucleotide polymorphisms (SNP...    »
 
Journal title abbreviation:
Carcinogenesis 
Year:
2008 
Journal volume:
29 
Journal issue:
Pages contribution:
351-5 
Language:
eng 
Print-ISSN:
0143-3334 
TUM Institution:
Frauenklinik und Poliklinik