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Document type:
journal article 
Author(s):
Frank, B; Wiestler, M; Kropp, S; Hemminki, K; Spurdle, AB; Sutter, C; Wappenschmidt, B; Chen, X; Beesley, J; Hopper, JL; Australian Breast Cancer Family Study Investigators,; Meindl, A; Kiechle, M; Slanger, T; Bugert, P; Schmutzler, RK; Bartram, CR; Flesch-Janys, D; Mutschelknauss, E; Ashton, K; Salazar, R; Webb, E; Hamann, U; Brauch, H; Justenhoven, C; Ko, YD; Brüning, T; Silva, Idos S; Johnson, N; Pharoah, PP; Dunning, AM; Pooley, KA; Chang-Claude, J; Easton, DF; Peto, J; Houlston, R; Gene Env...    »
 
Title:
Association of a common AKAP9 variant with breast cancer risk: a collaborative analysis. 
Abstract:
Data from several studies have suggested that polymorphisms in A-kinase anchoring proteins (AKAPs), which are key components of signal transduction, contribute to carcinogenesis. To evaluate the impact of AKAP variants on breast cancer risk, we genotyped six nonsynonymous single-nucleotide polymorphisms that were predicted to be deleterious and found two (M463I, 1389G>T and N2792S, 8375A>G) to be associated with an allele dose-dependent increase in risk of familial breast cancer in a German popu...    »
 
Journal title abbreviation:
J Natl Cancer Inst 
Year:
2008 
Journal volume:
100 
Journal issue:
Pages contribution:
437-42 
Language:
eng 
Print-ISSN:
0027-8874 
TUM Institution:
Frauenklinik und Poliklinik