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Dokumenttyp:
journal article 
Autor(en):
Knör, S; Sato, S; Huber, T; Morgenstern, A; Bruchertseifer, F; Schmitt, M; Kessler, H; Senekowitsch-Schmidtke, R; Magdolen, V; Seidl, C 
Titel:
Development and evaluation of peptidic ligands targeting tumour-associated urokinase plasminogen activator receptor (uPAR) for use in alpha-emitter therapy for disseminated ovarian cancer. 
Abstract:
PURPOSE: Among gynecologic malignancies, ovarian cancer has the highest mortality due to rapid peritoneal dissemination. Treatment failure particularly arises from failure to eliminate disseminated cells. Our aim was to develop peptidic radioligands targeting tumour cell-associated urokinase receptor (uPAR, CD87) for alpha-emitter therapy for advanced ovarian cancer. METHODS: DOTA-conjugated, uPAR-directed ligands were synthesised on solid-phase. Binding of peptides to human cells expressing uPA...    »
 
Zeitschriftentitel:
Eur J Nucl Med Mol Imaging 
Jahr:
2008 
Band / Volume:
35 
Heft / Issue:
Seitenangaben Beitrag:
53-64 
Sprache:
eng 
Print-ISSN:
1619-7070 
TUM Einrichtung:
Frauenklinik und Poliklinik; Nuklearmedizinische Klinik und Poliklinik