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Document type:
journal article 
Author(s):
Knör, S; Sato, S; Huber, T; Morgenstern, A; Bruchertseifer, F; Schmitt, M; Kessler, H; Senekowitsch-Schmidtke, R; Magdolen, V; Seidl, C 
Title:
Development and evaluation of peptidic ligands targeting tumour-associated urokinase plasminogen activator receptor (uPAR) for use in alpha-emitter therapy for disseminated ovarian cancer. 
Abstract:
PURPOSE: Among gynecologic malignancies, ovarian cancer has the highest mortality due to rapid peritoneal dissemination. Treatment failure particularly arises from failure to eliminate disseminated cells. Our aim was to develop peptidic radioligands targeting tumour cell-associated urokinase receptor (uPAR, CD87) for alpha-emitter therapy for advanced ovarian cancer. METHODS: DOTA-conjugated, uPAR-directed ligands were synthesised on solid-phase. Binding of peptides to human cells expressing uPA...    »
 
Journal title abbreviation:
Eur J Nucl Med Mol Imaging 
Year:
2008 
Journal volume:
35 
Journal issue:
Pages contribution:
53-64 
Language:
eng 
Print-ISSN:
1619-7070 
TUM Institution:
Frauenklinik und Poliklinik; Nuklearmedizinische Klinik und Poliklinik