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Document type:
journal article 
Author(s):
Kessenbrock, K; Fröhlich, L; Sixt, M; Lämmermann, T; Pfister, H; Bateman, A; Belaaouaj, A; Ring, J; Ollert, M; Fässler, R; Jenne, DE 
Title:
Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin. 
Abstract:
Neutrophil granulocytes form the body's first line of antibacterial defense, but they also contribute to tissue injury and noninfectious, chronic inflammation. Proteinase 3 (PR3) and neutrophil elastase (NE) are 2 abundant neutrophil serine proteases implicated in antimicrobial defense with overlapping and potentially redundant substrate specificity. Here, we unraveled a cooperative role for PR3 and NE in neutrophil activation and noninfectious inflammation in vivo, which we believe to be novel....    »
 
Journal title abbreviation:
J Clin Invest 
Year:
2008 
Journal volume:
118 
Journal issue:
Pages contribution:
2438-47 
Language:
eng 
Print-ISSN:
0021-9738 
TUM Institution:
Klinik und Poliklinik für Dermatologie und Allergologie