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Dokumenttyp:
journal article 
Autor(en):
Kalali, BN; Köllisch, G; Mages, J; Müller, T; Bauer, S; Wagner, H; Ring, J; Lang, R; Mempel, M; Ollert, M 
Titel:
Double-stranded RNA induces an antiviral defense status in epidermal keratinocytes through TLR3-, PKR-, and MDA5/RIG-I-mediated differential signaling. 
Abstract:
Emerging evidence suggests an important role for human epidermal keratinocytes in innate immune mechanisms against bacterial and viral skin infections. The proinflammatory effect of viral infections can be mimicked by double-stranded RNA (dsRNA). Herein, we demonstrate that keratinocytes express all known dsRNA sensing receptors at a constitutive and inducible level, and that they use several downstream signaling pathways leading to a broad pattern of gene expression, not only proinflammatory an...    »
 
Zeitschriftentitel:
J Immunol 
Jahr:
2008 
Band / Volume:
181 
Heft / Issue:
Seitenangaben Beitrag:
2694-704 
Sprache:
eng 
Print-ISSN:
0022-1767 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene; r Dermatologie und Allergologie