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Document type:
journal article 
Author(s):
Kalali, BN; Köllisch, G; Mages, J; Müller, T; Bauer, S; Wagner, H; Ring, J; Lang, R; Mempel, M; Ollert, M 
Title:
Double-stranded RNA induces an antiviral defense status in epidermal keratinocytes through TLR3-, PKR-, and MDA5/RIG-I-mediated differential signaling. 
Abstract:
Emerging evidence suggests an important role for human epidermal keratinocytes in innate immune mechanisms against bacterial and viral skin infections. The proinflammatory effect of viral infections can be mimicked by double-stranded RNA (dsRNA). Herein, we demonstrate that keratinocytes express all known dsRNA sensing receptors at a constitutive and inducible level, and that they use several downstream signaling pathways leading to a broad pattern of gene expression, not only proinflammatory an...    »
 
Journal title abbreviation:
J Immunol 
Year:
2008 
Journal volume:
181 
Journal issue:
Pages contribution:
2694-704 
Language:
eng 
Print-ISSN:
0022-1767 
TUM Institution:
r Medizinische Mikrobiologie, Immunologie und Hygiene; r Dermatologie und Allergologie