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Dokumenttyp:
journal article 
Autor(en):
Abe, K; Wechs, S; Kalaydjiev, S; Franz, TJ; Busch, DH; Fuchs, H; Soewarto, D; Behrendt, H; Wagner, S; Jakob, T; Hrabé de Angelis, M 
Titel:
Novel lymphocyte-independent mechanisms to initiate inflammatory arthritis via bone marrow-derived cells of Ali18 mutant mice. 
Abstract:
OBJECTIVE: In a large-scale ENU (N-ethyl-N-nitrosourea) mouse mutagenesis programme, we previously have identified and characterized a novel mutation Ali18 that causes inflammatory arthritis like lesions in peripheral joints. In this study, we analysed the immune system of Ali18 mice to understand mechanisms underlying the spontaneous inflammation. METHODS: Humoral and cellular components of the immune system were phenotyped by ELISA and flow cytometry. The contribution of the immune system for...    »
 
Zeitschriftentitel:
Rheumatology (Oxford) 
Jahr:
2008 
Band / Volume:
47 
Heft / Issue:
Seitenangaben Beitrag:
292-300 
Sprache:
eng 
Print-ISSN:
1462-0324 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene; r Dermatologie und Allergologie