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Dokumenttyp:
journal article 
Autor(en):
Jakob, T; Köllisch, GV; Howaldt, M; Bewersdorff, M; Rathkolb, B; Müller, ML; Sandholzer, N; Nitschke, L; Schiemann, M; Mempel, M; Ollert, M; Neubauer, A; Soewarto, DA; Kremmer, E; Ring, J; Behrendt, H; Flaswinkel, H 
Titel:
Novel mouse mutants with primary cellular immunodeficiencies generated by genome-wide mutagenesis. 
Abstract:
BACKGROUND: Primary cellular immunodeficiencies are a group of genetic disorders in which 1 or more components of the cellular immune system are lacking or dysfunctional. OBJECTIVE: We sought to identify novel mouse mutants that display primary cellular immunodeficiencies. METHODS: Genome-wide N-ethyl-N-nitrosourea mutagenesis was performed in mice, followed by a phenotype screen of immunologic blood parameters. RESULTS: We identified novel mouse mutants with isolated B-cell deficiency, combined...    »
 
Zeitschriftentitel:
J Allergy Clin Immunol 
Jahr:
2008 
Band / Volume:
121 
Heft / Issue:
Seitenangaben Beitrag:
179-184.e7 
Sprache:
eng 
Print-ISSN:
0091-6749 
TUM Einrichtung:
r Dermatologie und Allergologie