User: Guest  Login
Document type:
journal article 
Author(s):
Rauter, I; Krauth, MT; Westritschnig, K; Horak, F; Flicker, S; Gieras, A; Repa, A; Balic, N; Spitzauer, S; Huss-Marp, J; Brockow, K; Darsow, U; Behrendt, H; Ring, J; Kricek, F; Valent, P; Valenta, R 
Title:
Mast cell-derived proteases control allergic inflammation through cleavage of IgE. 
Abstract:
BACKGROUND: Cross-linking of mast cell-bound IgE releases proinflammatory mediators, cytokines, and proteolytic enzymes and is a key event in allergic inflammation. OBJECTIVE: We sought to study the effect of proteases released on effector cell activation on receptor-bound IgE and their possible role in the regulation of allergic inflammation. METHODS: Using molar ratios of purified recombinant tryptase and human IgE, we studied whether tryptase can cleave IgE. Similar experiments were performed...    »
 
Journal title abbreviation:
J Allergy Clin Immunol 
Year:
2008 
Journal volume:
121 
Journal issue:
Pages contribution:
197-202 
Language:
eng 
Print-ISSN:
0091-6749 
TUM Institution:
Klinik und Poliklinik für Dermatologie und Allergologie