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Dokumenttyp:
journal article 
Autor(en):
Rauter, I; Krauth, MT; Westritschnig, K; Horak, F; Flicker, S; Gieras, A; Repa, A; Balic, N; Spitzauer, S; Huss-Marp, J; Brockow, K; Darsow, U; Behrendt, H; Ring, J; Kricek, F; Valent, P; Valenta, R 
Titel:
Mast cell-derived proteases control allergic inflammation through cleavage of IgE. 
Abstract:
BACKGROUND: Cross-linking of mast cell-bound IgE releases proinflammatory mediators, cytokines, and proteolytic enzymes and is a key event in allergic inflammation. OBJECTIVE: We sought to study the effect of proteases released on effector cell activation on receptor-bound IgE and their possible role in the regulation of allergic inflammation. METHODS: Using molar ratios of purified recombinant tryptase and human IgE, we studied whether tryptase can cleave IgE. Similar experiments were performed...    »
 
Zeitschriftentitel:
J Allergy Clin Immunol 
Jahr:
2008 
Band / Volume:
121 
Heft / Issue:
Seitenangaben Beitrag:
197-202 
Sprache:
eng 
Print-ISSN:
0091-6749 
TUM Einrichtung:
r Dermatologie und Allergologie