Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Ceyhan, GO; Demir, IE; Altintas, B; Rauch, U; Thiel, G; Müller, MW; Giese, NA; Friess, H; Schäfer, KH 
Titel:
Neural invasion in pancreatic cancer: a mutual tropism between neurons and cancer cells. 
Abstract:
Neural invasion by pancreatic cancer cells (PCC) worsens the prognosis and frequently limits curative resection. We established a novel in-vitro model in which T3M4-PCCs were co-cultured with either isolated myenteric plexus cells (MP) or dorsal root ganglia (DRG) of newborn rats within a three-dimensional extracellular matrix gel. The close vicinity of MP or DRG to T3M4-PCCs induced early morphologic changes on T3M4-PCCs at the migration front prior to the migration process with elongated and n...    »
 
Zeitschriftentitel:
Biochem Biophys Res Commun 
Jahr:
2008 
Band / Volume:
374 
Heft / Issue:
Seitenangaben Beitrag:
442-7 
Sprache:
eng 
Print-ISSN:
0006-291X 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik