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Document type:
journal article 
Author(s):
Ceyhan, GO; Demir, IE; Altintas, B; Rauch, U; Thiel, G; Müller, MW; Giese, NA; Friess, H; Schäfer, KH 
Title:
Neural invasion in pancreatic cancer: a mutual tropism between neurons and cancer cells. 
Abstract:
Neural invasion by pancreatic cancer cells (PCC) worsens the prognosis and frequently limits curative resection. We established a novel in-vitro model in which T3M4-PCCs were co-cultured with either isolated myenteric plexus cells (MP) or dorsal root ganglia (DRG) of newborn rats within a three-dimensional extracellular matrix gel. The close vicinity of MP or DRG to T3M4-PCCs induced early morphologic changes on T3M4-PCCs at the migration front prior to the migration process with elongated and n...    »
 
Journal title abbreviation:
Biochem Biophys Res Commun 
Year:
2008 
Journal volume:
374 
Journal issue:
Pages contribution:
442-7 
Language:
eng 
Print-ISSN:
0006-291X 
TUM Institution:
Chirurgiesche Klinik und Poliklinik