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Document type:
journal article 
Author(s):
Michalski, CW; Selvaggi, F; Bartel, M; Mitkus, T; Gorbachevski, A; Giese, T; Sebastiano, PD; Giese, NA; Friess, H 
Title:
Altered anti-inflammatory response of mononuclear cells to neuropeptide PACAP is associated with deregulation of NF-{kappa}B in chronic pancreatitis. 
Abstract:
Although it is recognized that neurogenic influences contribute to progression of chronic inflammatory diseases, the molecular basis of neuroimmune interactions in the pathogenesis of chronic pancreatitis (CP) is not well defined. Here we report that responsiveness of peripheral blood mononuclear cells (PBMC) to the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) is altered in CP. Expression of PACAP and its receptors in human CP was analyzed with quantitative RT-PCR, las...    »
 
Journal title abbreviation:
Am J Physiol Gastrointest Liver Physiol 
Year:
2008 
Journal volume:
294 
Journal issue:
Pages contribution:
G50-7 
Language:
eng 
Print-ISSN:
0193-1857 
TUM Institution:
Chirurgiesche Klinik und Poliklinik