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Document type:
journal article 
Author(s):
Popov, Y; Patsenker, E; Stickel, F; Zaks, J; Bhaskar, KR; Niedobitek, G; Kolb, A; Friess, H; Schuppan, D 
Title:
Integrin alphavbeta6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies. 
Abstract:
BACKGROUND/AIMS: The integrin alphavbeta6 promotes proliferation of specialized epithelia and acts as a receptor for the activation of latent TGFbeta1. We studied alphavbeta6 expression in experimental and human liver fibrosis and the potential of its pharmacological inhibition for treatment of hepatic fibrosis. METHODS: alphavbeta6 expression was studied by quantitative PCR and immunohistochemistry in rats with cirrhosis due to bile duct ligation (BDL), administration of thioacetamide (TAA), in...    »
 
Journal title abbreviation:
J Hepatol 
Year:
2008 
Journal volume:
48 
Journal issue:
Pages contribution:
453-64 
Language:
eng 
Print-ISSN:
0168-8278 
TUM Institution:
Chirurgiesche Klinik und Poliklinik