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Document type:
journal article 
Author(s):
Herkert, NM; Eckert, S; Eyer, P; Bumm, R; Weber, G; Thiermann, H; Worek, F 
Title:
Identical kinetics of human erythrocyte and muscle acetylcholinesterase with respect to carbamate pre-treatment, residual activity upon soman challenge and spontaneous reactivation after withdrawal of the inhibitors. 
Abstract:
The efficacy of oxime treatment in soman poisoning is limited due to rapid aging of inhibited acetylcholinesterase (AChE). Pre-treatment with carbamates was shown to improve antidotal treatment substantially. Recently, by using a dynamically working in vitro model with real-time determination of membrane-bound AChE activity, we were able to demonstrate that pre-inhibition of human erythrocyte AChE with pyridostigmine or physostigmine resulted in a markedly higher residual AChE activity after inh...    »
 
Journal title abbreviation:
Toxicology 
Year:
2008 
Journal volume:
246 
Journal issue:
2-3 
Pages contribution:
188-92 
Language:
eng 
Print-ISSN:
0300-483X 
TUM Institution:
Chirurgiesche Klinik und Poliklinik