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Dokumenttyp:
journal article 
Autor(en):
Sewald, X; Gebert-Vogl, B; Prassl, S; Barwig, I; Weiss, E; Fabbri, M; Osicka, R; Schiemann, M; Busch, DH; Semmrich, M; Holzmann, B; Sebo, P; Haas, R 
Titel:
Integrin subunit CD18 Is the T-lymphocyte receptor for the Helicobacter pylori vacuolating cytotoxin. 
Abstract:
Helicobacter pylori infection is associated with gastritis, ulcerations, and gastric adenocarcinoma. H. pylori secretes the vacuolating cytotoxin (VacA), a major pathogenicity factor. VacA has immunosuppressive effects, inhibiting interleukin-2 (IL-2) secretion by interference with the T cell receptor/IL-2 signaling pathway at the level of calcineurin, the Ca2+-calmodulin-dependent phosphatase. Here, we show that VacA efficiently enters activated, migrating primary human T lymphocytes by binding...    »
 
Zeitschriftentitel:
Cell Host Microbe 
Jahr:
2008 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
20-9 
Sprache:
eng 
Print-ISSN:
1931-3128 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik