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Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article 
Author(s):
Sewald, X; Gebert-Vogl, B; Prassl, S; Barwig, I; Weiss, E; Fabbri, M; Osicka, R; Schiemann, M; Busch, DH; Semmrich, M; Holzmann, B; Sebo, P; Haas, R 
Title:
Integrin subunit CD18 Is the T-lymphocyte receptor for the Helicobacter pylori vacuolating cytotoxin. 
Abstract:
Helicobacter pylori infection is associated with gastritis, ulcerations, and gastric adenocarcinoma. H. pylori secretes the vacuolating cytotoxin (VacA), a major pathogenicity factor. VacA has immunosuppressive effects, inhibiting interleukin-2 (IL-2) secretion by interference with the T cell receptor/IL-2 signaling pathway at the level of calcineurin, the Ca2+-calmodulin-dependent phosphatase. Here, we show that VacA efficiently enters activated, migrating primary human T lymphocytes by binding...    »
 
Journal title abbreviation:
Cell Host Microbe 
Year:
2008 
Journal volume:
Journal issue:
Pages contribution:
20-9 
Language:
eng 
Print-ISSN:
1931-3128 
TUM Institution:
Chirurgische Klinik und Poliklinik