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Dokumenttyp:
journal article 
Autor(en):
Beckermann, BM; Kallifatidis, G; Groth, A; Frommhold, D; Apel, A; Mattern, J; Salnikov, AV; Moldenhauer, G; Wagner, W; Diehlmann, A; Saffrich, R; Schubert, M; Ho, AD; Giese, N; Büchler, MW; Friess, H; Büchler, P; Herr, I 
Titel:
VEGF expression by mesenchymal stem cells contributes to angiogenesis in pancreatic carcinoma. 
Abstract:
Little is known about the factors that enable the mobilisation of human mesenchymal stem cells (MSC) from the bone marrow into the blood stream and their recruitment to and retention in the tumour. We found specific migration of MSC towards growth factors present in pancreatic tumours, such as PDGF, EGF, VEGF and specific inhibitors Glivec, Erbitux and Avastin interfered with migration. Within a few hours, MSC migrated into spheroids consisting of pancreatic cancer cells, fibroblasts and endothe...    »
 
Zeitschriftentitel:
Br J Cancer 
Jahr:
2008 
Band / Volume:
99 
Heft / Issue:
Seitenangaben Beitrag:
622-31 
Sprache:
eng 
Print-ISSN:
0007-0920 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik