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Document type:
journal article 
Author(s):
Beckermann, BM; Kallifatidis, G; Groth, A; Frommhold, D; Apel, A; Mattern, J; Salnikov, AV; Moldenhauer, G; Wagner, W; Diehlmann, A; Saffrich, R; Schubert, M; Ho, AD; Giese, N; Büchler, MW; Friess, H; Büchler, P; Herr, I 
Title:
VEGF expression by mesenchymal stem cells contributes to angiogenesis in pancreatic carcinoma. 
Abstract:
Little is known about the factors that enable the mobilisation of human mesenchymal stem cells (MSC) from the bone marrow into the blood stream and their recruitment to and retention in the tumour. We found specific migration of MSC towards growth factors present in pancreatic tumours, such as PDGF, EGF, VEGF and specific inhibitors Glivec, Erbitux and Avastin interfered with migration. Within a few hours, MSC migrated into spheroids consisting of pancreatic cancer cells, fibroblasts and endothe...    »
 
Journal title abbreviation:
Br J Cancer 
Year:
2008 
Journal volume:
99 
Journal issue:
Pages contribution:
622-31 
Language:
eng 
Print-ISSN:
0007-0920 
TUM Institution:
Chirurgiesche Klinik und Poliklinik