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Dokumenttyp:
journal article 
Autor(en):
Falguières, T; Maak, M; von Weyhern, C; Sarr, M; Sastre, X; Poupon, MF; Robine, S; Johannes, L; Janssen, KP 
Titel:
Human colorectal tumors and metastases express Gb3 and can be targeted by an intestinal pathogen-based delivery tool. 
Abstract:
The targeting of solid tumors requires delivery tools that resist intracellular and extracellular inactivation, and that are taken up specifically by tumor cells. We have shown previously that the recombinant nontoxic B-subunit of Shiga toxin (STxB) can serve as a delivery tool to target digestive tumors in animal models. The aim of this study was to expand these experiments to human colorectal cancer. Tissue samples of normal colon, benign adenomas, colorectal carcinomas, and liver metastases f...    »
 
Zeitschriftentitel:
Mol Cancer Ther 
Jahr:
2008 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
2498-508 
Sprache:
eng 
Print-ISSN:
1535-7163 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik