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Document type:
journal article 
Author(s):
Erkan, M; Michalski, CW; Rieder, S; Reiser-Erkan, C; Abiatari, I; Kolb, A; Giese, NA; Esposito, I; Friess, H; Kleeff, J 
Title:
The activated stroma index is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma. 
Abstract:
BACKGROUND AND AIMS: Pancreatic ductal adenocarcinoma (PDAC) is a highly desmoplastic tumor with an innate resistance to therapy. Pancreatic stellate cells (PSCs) produce this excessively desmoplastic microenvironment. The impact of PSC activity on PDAC behavior in vivo is analyzed. METHODS: 233 patients who underwent surgery for PDAC were evaluated by immunohistochemistry using antibodies against alpha-smooth muscle actin as a marker of PSC activity. Aniline was used to stain collagen depositio...    »
 
Journal title abbreviation:
Clin Gastroenterol Hepatol 
Year:
2008 
Journal volume:
Journal issue:
10 
Pages contribution:
1155-61 
Language:
eng 
Print-ISSN:
1542-3565 
TUM Institution:
Chirurgiesche Klinik und Poliklinik