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Dokumenttyp:
journal article 
Autor(en):
Seidler, B; Schmidt, A; Mayr, U; Nakhai, H; Schmid, RM; Schneider, G; Saur, D 
Titel:
A Cre-loxP-based mouse model for conditional somatic gene expression and knockdown in vivo by using avian retroviral vectors. 
Abstract:
Site- and time-specific somatic gene transfer by using the avian sarcoma-leukosis retrovirus RCAS (replication-competent avian sarcoma-leukosis virus long terminal repeat with splice acceptor) has been shown to be a powerful tool to analyze gene function in vivo. RCAS retroviruses that express the avian subgroup A envelope transduce only mammalian cells genetically engineered to express the avian retroviral receptor, tumor virus A (TVA). Here, we generated a knockin mouse line termed LSL-R26(Tva...    »
 
Zeitschriftentitel:
Proc Natl Acad Sci U S A 
Jahr:
2008 
Band / Volume:
105 
Heft / Issue:
29 
Seitenangaben Beitrag:
10137-42 
Sprache:
eng 
Print-ISSN:
0027-8424 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik