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Document type:
journal article 
Author(s):
Gu, P; Xing, X; Tänzer, M; Röcken, C; Weichert, W; Ivanauskas, A; Pross, M; Peitz, U; Malfertheiner, P; Schmid, RM; Ebert, MP 
Title:
Frequent loss of TIMP-3 expression in progression of esophageal and gastric adenocarcinomas. 
Abstract:
Tissue inhibitor of metalloproteinase 3 (TIMP-3) promoter methylation has been linked to loss of TIMP-3 expression in various cancers. In this study, we analyzed TIMP-3 gene methylation using MethyLight assay and TIMP-3 mRNA expression using reverse transcription-polymerase chain reaction analysis in 22 esophageal cancers, 27 gastric carcinomas, and 7 cancer cell lines. We also analyzed TIMP-3 protein expression by immunohistochemistry and its association with clinicopathological characteristics...    »
 
Journal title abbreviation:
Neoplasia 
Year:
2008 
Journal volume:
10 
Journal issue:
Pages contribution:
563-72 
Language:
eng 
Print-ISSN:
1522-8002 
TUM Institution:
II. Medizinische Klinik und Poliklinik