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Dokumenttyp:
journal article 
Autor(en):
Marozin, S; Altomonte, J; Stadler, F; Thasler, WE; Schmid, RM; Ebert, O 
Titel:
Inhibition of the IFN-beta response in hepatocellular carcinoma by alternative spliced isoform of IFN regulatory factor-3. 
Abstract:
The intrinsic oncolytic specificity of vesicular stomatitis virus (VSV) is currently being exploited to develop alternative therapeutic strategies for hepatocellular carcinoma (HCC). We have observed earlier that, in contrast to cultured human HCC cells, primary human hepatocytes (PHHs) are refractory to VSV infection. Impairment of the type I interferon (IFN) pathway in HCC cells has been suggested to be the mechanism by which these cells become susceptible to VSV infection. The goal of this st...    »
 
Zeitschriftentitel:
Mol Ther 
Jahr:
2008 
Band / Volume:
16 
Heft / Issue:
11 
Seitenangaben Beitrag:
1789-97 
Sprache:
eng 
Print-ISSN:
1525-0016 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik