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Dokumenttyp:
journal article 
Autor(en):
Nakhai, H; Siveke, JT; Mendoza-Torres, L; Schmid, RM 
Titel:
Conditional inactivation of Myc impairs development of the exocrine pancreas. 
Abstract:
Recent studies have shown that Wnt/beta-catenin signaling is essential for development of the exocrine pancreas, but the role of beta-catenin-dependent target genes such as Myc during pancreatic development is not well known. Here, we show that tissue-specific deletion of Myc causes a slightly accelerated differentiation of pancreatic epithelial cells into endocrine cells and perturbs the proliferation of pancreatic progenitors and acinar precursor cells during early development, resulting in a...    »
 
Zeitschriftentitel:
Development 
Jahr:
2008 
Band / Volume:
135 
Heft / Issue:
19 
Seitenangaben Beitrag:
3191-6 
Sprache:
eng 
Print-ISSN:
0950-1991 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik