User: Guest  Login
Document type:
journal article 
Author(s):
Nakhai, H; Siveke, JT; Klein, B; Mendoza-Torres, L; Mazur, PK; Algül, H; Radtke, F; Strobl, L; Zimber-Strobl, U; Schmid, RM 
Title:
Conditional ablation of Notch signaling in pancreatic development. 
Abstract:
The role of the Notch signaling members Notch1, Notch2 and Rbpj in exocrine pancreatic development is not well defined. We therefore analyzed conditional pancreas-specific Rbpj and combined Notch1/Notch2 knockout mice using Ptf1a(+/Cre(ex1)) mice crossed with floxed Rbpj or Notch1/Notch2 mice. Mice were analyzed at different embryonic stages for pancreatic exocrine and endocrine development. The absence of Rbpj in pancreatic progenitor cells impaired exocrine pancreas development up to embryonic...    »
 
Journal title abbreviation:
Development 
Year:
2008 
Journal volume:
135 
Journal issue:
16 
Pages contribution:
2757-65 
Language:
eng 
Print-ISSN:
0950-1991 
TUM Institution:
II. Medizinische Klinik und Poliklinik