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Dokumenttyp:
journal article 
Autor(en):
Nakhai, H; Siveke, JT; Klein, B; Mendoza-Torres, L; Mazur, PK; Algül, H; Radtke, F; Strobl, L; Zimber-Strobl, U; Schmid, RM 
Titel:
Conditional ablation of Notch signaling in pancreatic development. 
Abstract:
The role of the Notch signaling members Notch1, Notch2 and Rbpj in exocrine pancreatic development is not well defined. We therefore analyzed conditional pancreas-specific Rbpj and combined Notch1/Notch2 knockout mice using Ptf1a(+/Cre(ex1)) mice crossed with floxed Rbpj or Notch1/Notch2 mice. Mice were analyzed at different embryonic stages for pancreatic exocrine and endocrine development. The absence of Rbpj in pancreatic progenitor cells impaired exocrine pancreas development up to embryonic...    »
 
Zeitschriftentitel:
Development 
Jahr:
2008 
Band / Volume:
135 
Heft / Issue:
16 
Seitenangaben Beitrag:
2757-65 
Sprache:
eng 
Print-ISSN:
0950-1991 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik