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Document type:
journal article 
Author(s):
Annecke, K; Schmitt, M; Euler, U; Zerm, M; Paepke, D; Paepke, S; von Minckwitz, G; Thomssen, C; Harbeck, N 
Title:
uPA and PAI-1 in breast cancer: review of their clinical utility and current validation in the prospective NNBC-3 trial. 
Abstract:
The plasminogen activator system is a complex system with multiple interactions and members participating in fibrinolysis, cell migration, angiogenesis, wound healing, embryogenesis, tumor cell dissemination, and metastasis in a variety of solid tumors. Increased levels of uPA and/or PAI-1 in primary tumor tissues of breast cancer patients correlate with tumor aggressiveness and poor clinical outcome. Patients with high tumor tissue antigen content of uPA and/or PAI-1 have a worse probability of...    »
 
Journal title abbreviation:
Adv Clin Chem 
Year:
2008 
Journal volume:
45 
Pages contribution:
31-45 
Language:
eng 
Print-ISSN:
0065-2423 
TUM Institution:
Frauenklinik und Poliklinik