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Document type:
journal article 
Author(s):
Hammer, M; Richter, S; Kobuch, K; Mata, N; Schweitzer, D 
Title:
Intrinsic tissue fluorescence in an organotypic perfusion culture of the porcine ocular fundus exposed to blue light and free radicals. 
Abstract:
BACKGROUND: A wide variety of pathological pathways may result in age-related macular degeneration. Because of its complexity, there is no comprehensive model of the disease yet. One key feature is the accumulation of the autofluorescent pigment lipofuscin in the retinal pigment epithelium (RPE). Thus, we developed an organotypic perfusion culture model of the porcine ocular fundus, generating lipofuscin under exposure to blue light and hydrogen peroxide. METHODS: Porcine fundi (choroid, Bruch's...    »
 
Journal title abbreviation:
Graefes Arch Clin Exp Ophthalmol 
Year:
2008 
Journal volume:
246 
Journal issue:
Pages contribution:
979-88 
Language:
eng 
Print-ISSN:
0721-832X 
TUM Institution:
Augenklinik und Poliklinik