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Dokumenttyp:
journal article 
Autor(en):
Hammer, M; Richter, S; Kobuch, K; Mata, N; Schweitzer, D 
Titel:
Intrinsic tissue fluorescence in an organotypic perfusion culture of the porcine ocular fundus exposed to blue light and free radicals. 
Abstract:
BACKGROUND: A wide variety of pathological pathways may result in age-related macular degeneration. Because of its complexity, there is no comprehensive model of the disease yet. One key feature is the accumulation of the autofluorescent pigment lipofuscin in the retinal pigment epithelium (RPE). Thus, we developed an organotypic perfusion culture model of the porcine ocular fundus, generating lipofuscin under exposure to blue light and hydrogen peroxide. METHODS: Porcine fundi (choroid, Bruch's...    »
 
Zeitschriftentitel:
Graefes Arch Clin Exp Ophthalmol 
Jahr:
2008 
Band / Volume:
246 
Heft / Issue:
Seitenangaben Beitrag:
979-88 
Sprache:
eng 
Print-ISSN:
0721-832X 
TUM Einrichtung:
Augenklinik und Poliklinik