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Document type:
journal article 
Author(s):
Klier, M; Anastasov, N; Hermann, A; Meindl, T; Angermeier, D; Raffeld, M; Fend, F; Quintanilla-Martinez, L 
Title:
Specific lentiviral shRNA-mediated knockdown of cyclin D1 in mantle cell lymphoma has minimal effects on cell survival and reveals a regulatory circuit with cyclin D2. 
Abstract:
Cyclin D1 overexpression is the hallmark of mantle cell lymphoma (MCL). However, the importance of cyclin D1 in the maintenance and progression of the disease remains to be defined. The aim of this study was to elucidate the role of cyclin D1 overexpression using an efficient cyclin D1-shRNA and a lentiviral system in well-characterized MCL cell lines. Surprisingly, the knockdown of cyclin D1 led to a moderate retardation in growth, without induction of apoptosis. The cyclin D1-shRNA-transduced...    »
 
Journal title abbreviation:
Leukemia 
Year:
2008 
Journal volume:
22 
Journal issue:
11 
Pages contribution:
2097-105 
Language:
eng 
Print-ISSN:
0887-6924 
TUM Institution:
r Toxikologie und Umwelthygiene