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Document type:
journal article 
Author(s):
Vega, VL; Rodríguez-Silva, M; Frey, T; Gehrmann, M; Diaz, JC; Steinem, C; Multhoff, G; Arispe, N; De Maio, A 
Title:
Hsp70 translocates into the plasma membrane after stress and is released into the extracellular environment in a membrane-associated form that activates macrophages. 
Abstract:
Heat shock proteins (hsps) are intracellular chaperones that play a key role in the recovery from stress. Hsp70, the major stress-induced hsp, has been found in the extracellular medium and is capable of activating immune cells. The mechanism involved in Hsp70 release is controversial because this protein does not present a consensual secretory signal. In this study, we have shown that Hsp70 integrates into artificial lipid bilayer openings of ion conductance pathways. In addition, this protein...    »
 
Journal title abbreviation:
J Immunol 
Year:
2008 
Journal volume:
180 
Journal issue:
Pages contribution:
4299-307 
Language:
eng 
Print-ISSN:
0022-1767 
TUM Institution:
Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie