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Dokumenttyp:
journal article 
Autor(en):
Vega, VL; Rodríguez-Silva, M; Frey, T; Gehrmann, M; Diaz, JC; Steinem, C; Multhoff, G; Arispe, N; De Maio, A 
Titel:
Hsp70 translocates into the plasma membrane after stress and is released into the extracellular environment in a membrane-associated form that activates macrophages. 
Abstract:
Heat shock proteins (hsps) are intracellular chaperones that play a key role in the recovery from stress. Hsp70, the major stress-induced hsp, has been found in the extracellular medium and is capable of activating immune cells. The mechanism involved in Hsp70 release is controversial because this protein does not present a consensual secretory signal. In this study, we have shown that Hsp70 integrates into artificial lipid bilayer openings of ion conductance pathways. In addition, this protein...    »
 
Zeitschriftentitel:
J Immunol 
Jahr:
2008 
Band / Volume:
180 
Heft / Issue:
Seitenangaben Beitrag:
4299-307 
Sprache:
eng 
Print-ISSN:
0022-1767 
TUM Einrichtung:
r Strahlentherapie und Radiologische Onkologie