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Document type:
journal article 
Author(s):
Quasdorff, M; Hösel, M; Odenthal, M; Zedler, U; Bohne, F; Gripon, P; Dienes, HP; Drebber, U; Stippel, D; Goeser, T; Protzer, U 
Title:
A concerted action of HNF4alpha and HNF1alpha links hepatitis B virus replication to hepatocyte differentiation. 
Abstract:
Hepatitis B virus (HBV) is an important human pathogen, which targets the liver extremely efficient, gaining access to hepatocytes by a so far unknown receptor and replicating in a hepatocyte-specific fashion. Cell differentiation seems to determine HBV replication. We here show that the level of hepatocyte differentiation, as indicated by hepatocyte polarization and metabolic activity, is closely correlated to the transcription of the HBV RNA pregenome. Pregenome transcription determined the le...    »
 
Journal title abbreviation:
Cell Microbiol 
Year:
2008 
Journal volume:
10 
Journal issue:
Pages contribution:
1478-90 
Language:
eng 
Print-ISSN:
1462-5814 
TUM Institution:
Institut für Virologie