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Document type:
journal article 
Author(s):
Jenke, AC; Wilhelm, AD; Orth, V; Lipps, HJ; Protzer, U; Wirth, S 
Title:
Long-term suppression of hepatitis B virus replication by short hairpin RNA expression using the scaffold/matrix attachment region-based replicating vector system pEPI-1. 
Abstract:
Since the emergence of viral resistance of hepatitis B virus (HBV) during treatment is becoming an important issue even with newer drugs, there is a need for alternative treatment options such as, for example, RNA interference (RNAi) technology. While short-term suppression of HBV replication is easily achieved with small interfering RNA oligonucleotides, this is not the case for long-term suppression due to the lack of an optimal vector system. Based on the nonviral scaffold/matrix attachment r...    »
 
Journal title abbreviation:
Antimicrob Agents Chemother 
Year:
2008 
Journal volume:
52 
Journal issue:
Pages contribution:
2355-9 
Language:
eng 
Print-ISSN:
0066-4804 
TUM Institution:
Institut für Virologie