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Document type:
journal article 
Author(s):
Malaisé, M; Schätzl, HM; Bürkle, A 
Title:
The octarepeat region of prion protein, but not the TM1 domain, is important for the antioxidant effect of prion protein. 
Abstract:
The cellular prion protein (PrP(c)) plays a crucial role in the pathogenesis of prion diseases, but its physiological function is far from understood. Several candidate functions have been proposed including binding and internalization of metal ions, a superoxide dismutase-like activity, regulation of cellular antioxidant activities, and signal transduction. The transmembrane (TM1) region of PrP(c) (residues 110-135) is particularly interesting because of its very high evolutionary conservation....    »
 
Journal title abbreviation:
Free Radic Biol Med 
Year:
2008 
Journal volume:
45 
Journal issue:
12 
Pages contribution:
1622-30 
Language:
eng 
Print-ISSN:
0891-5849 
TUM Institution:
Institut für Virologie