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Document type:
journal article 
Author(s):
Gilch, S; Krammer, C; Schätzl, HM 
Title:
Targeting prion proteins in neurodegenerative disease. 
Abstract:
BACKGROUND: Spongiform neurodegeneration is the pathological hallmark of individuals suffering from prion disease. These disorders, whose manifestation is sporadic, familial or acquired by infection, are caused by accumulation of the aberrantly folded isoform of the cellular prion protein (PrP(c)), termed PrP(Sc). Although usually rare, prion disorders are inevitably fatal and transferrable by infection. OBJECTIVE: Pathology is restricted to the central nervous system and premortem diagnosis is...    »
 
Journal title abbreviation:
Expert Opin Biol Ther 
Year:
2008 
Journal volume:
Journal issue:
Pages contribution:
923-40 
Language:
eng 
Print-ISSN:
1471-2598 
TUM Institution:
r Virologie