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Document type:
journal article 
Author(s):
Breckwoldt, MO; Chen, JW; Stangenberg, L; Aikawa, E; Rodriguez, E; Qiu, S; Moskowitz, MA; Weissleder, R 
Title:
Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase. 
Abstract:
Inflammation can extend ischemic brain injury and adversely affect outcome in experimental animal models. A key difficulty in translating animal studies to humans is the lack of a definitive method to confirm and track inflammation in the brain in vivo. Myeloperoxidase (MPO), a key inflammatory enzyme secreted by activated neutrophils and macrophages/microglia, can generate highly reactive oxygen species to cause additional damage in cerebral ischemia. We report here that a functional, enzyme-ac...    »
 
Journal title abbreviation:
Proc Natl Acad Sci U S A 
Year:
2008 
Journal volume:
105 
Journal issue:
47 
Pages contribution:
18584-9 
Language:
eng 
Print-ISSN:
0027-8424 
TUM Institution:
r Neuroradiologie