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Document type:
journal article 
Author(s):
Oertel, BG; Preibisch, C; Wallenhorst, T; Hummel, T; Geisslinger, G; Lanfermann, H; Lötsch, J 
Title:
Differential opioid action on sensory and affective cerebral pain processing. 
Abstract:
Low doses of morphine, the most commonly used opioid analgesic, have been shown to significantly reduce the affective but not the sensory intensive dimension of pain. This suggests differential dose-response relationships of opioid analgesia on the sensory and affective components of pain. We investigated the effects of different alfentanil plasma concentration levels (0, 19.6+/-2.7, 47.2+/-7.6, and 76.6+/-11.3 ng/ml) on pain-related brain activation achieved by short pulses of gaseous CO(2) del...    »
 
Journal title abbreviation:
Clin Pharmacol Ther 
Year:
2008 
Journal volume:
83 
Journal issue:
Pages contribution:
577-88 
Language:
eng 
Print-ISSN:
0009-9236 
TUM Institution:
Abteilung für Neuroradiologie