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Dokumenttyp:
journal article 
Autor(en):
Berg, T; Fliegauf, M; Burger, J; Staege, MS; Liu, S; Martinez, N; Heidenreich, O; Burdach, S; Haferlach, T; Werner, MH; Lübbert, M 
Titel:
Transcriptional upregulation of p21/WAF/Cip1 in myeloid leukemic blasts expressing AML1-ETO. 
Abstract:
An inducible model for conditional expression of AML1-ETO in myeloid U-937 cells was generated previously to determine cellular effects of AML1-ETO and to identify target genes. Induction of AML1-ETO expression in U-937 resulted in reduced cell growth, G1 arrest and apoptosis. Microarray analysis showed more genes up-regulated than down-regulated (180 vs. 69). Clustering of AML1-ETO-positive and -negative cell lines was possible based on these differentially expressed genes. p21/WAF/Cip1 (CDKN1A...    »
 
Zeitschriftentitel:
Haematologica 
Jahr:
2008 
Band / Volume:
93 
Heft / Issue:
11 
Seitenangaben Beitrag:
1728-33 
Sprache:
eng 
Print-ISSN:
0390-6078 
TUM Einrichtung:
Kinderklinik und Poliklinik