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Document type:
journal article 
Author(s):
Möricke, A; Reiter, A; Zimmermann, M; Gadner, H; Stanulla, M; Dördelmann, M; Löning, L; Beier, R; Ludwig, WD; Ratei, R; Harbott, J; Boos, J; Mann, G; Niggli, F; Feldges, A; Henze, G; Welte, K; Beck, JD; Klingebiel, T; Niemeyer, C; Zintl, F; Bode, U; Urban, C; Wehinger, H; Niethammer, D; Riehm, H; Schrappe, M; German-Austrian-Swiss ALL-BFM Study Group 
Title:
Risk-adjusted therapy of acute lymphoblastic leukemia can decrease treatment burden and improve survival: treatment results of 2169 unselected pediatric and adolescent patients enrolled in the trial ALL-BFM 95. 
Abstract:
The trial ALL-BFM 95 for treatment of childhood acute lymphoblastic leukemia was designed to reduce acute and long-term toxicity in selected patient groups with favorable prognosis and to improve outcome in poor-risk groups by treatment intensification. These aims were pursued through a stratification strategy using white blood cell count, age, immunophenotype, treatment response, and unfavorable genetic aberrations providing an excellent discrimination of risk groups. Estimated 6-year event-fre...    »
 
Journal title abbreviation:
Blood 
Year:
2008 
Journal volume:
111 
Journal issue:
Pages contribution:
4477-89 
Language:
eng 
Print-ISSN:
0006-4971 
TUM Institution:
Kinderklinik und Poliklinik