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Document type:
journal article 
Author(s):
Kopitz, C; Gerg, M; Gansbacher, B; Krüger, A 
Title:
Plasminogen activator inhibitor-2, but not cystatin C, inhibits the prometastatic activity of tissue inhibitor of metalloproteinases-1 in the liver. 
Abstract:
Formation of multiple and scattered metastases in target organs, leading to disruption of organ functional integrity, is the death-determining step for most lethal cancers. In the clinic, elevated expression of tissue inhibitor of metalloproteinases-1 (TIMP-1) is often associated with increased aggressiveness of cancer. We demonstrated that elevated host expression of TIMP-1 leads to the promotion of scattered liver metastases in mice, associated with increased activity of cysteine proteases (CP...    »
 
Journal title abbreviation:
Hum Gene Ther 
Year:
2008 
Journal volume:
19 
Journal issue:
10 
Pages contribution:
1039-49 
Language:
eng 
Print-ISSN:
1043-0342 
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung