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Dokumenttyp:
journal article 
Autor(en):
Kopitz, C; Gerg, M; Gansbacher, B; Krüger, A 
Titel:
Plasminogen activator inhibitor-2, but not cystatin C, inhibits the prometastatic activity of tissue inhibitor of metalloproteinases-1 in the liver. 
Abstract:
Formation of multiple and scattered metastases in target organs, leading to disruption of organ functional integrity, is the death-determining step for most lethal cancers. In the clinic, elevated expression of tissue inhibitor of metalloproteinases-1 (TIMP-1) is often associated with increased aggressiveness of cancer. We demonstrated that elevated host expression of TIMP-1 leads to the promotion of scattered liver metastases in mice, associated with increased activity of cysteine proteases (CP...    »
 
Zeitschriftentitel:
Hum Gene Ther 
Jahr:
2008 
Band / Volume:
19 
Heft / Issue:
10 
Seitenangaben Beitrag:
1039-49 
Sprache:
eng 
Print-ISSN:
1043-0342 
TUM Einrichtung:
r experimentelle Onkologie und Therapieforschung