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Dokumenttyp:
journal article 
Autor(en):
Weinmeister, P; Lukowski, R; Linder, S; Traidl-Hoffmann, C; Hengst, L; Hofmann, F; Feil, R 
Titel:
Cyclic guanosine monophosphate-dependent protein kinase I promotes adhesion of primary vascular smooth muscle cells. 
Abstract:
The cyclic guanosine monophosphate (cGMP)/cGMP-dependent protein kinase type I (cGKI) pathway regulates many cellular functions. The current study shows that 8-Br-cGMP stimulates the number of attached primary but not that of subcultured murine vascular smooth muscle cells (VSMCs). These effects of 8-Br-cGMP require the presence of cGKI. In agreement with previous studies, cGKI inhibited the number of cells in repeatedly passaged murine VSMCs. Activation of the cGMP/cGKI pathway in freshly isola...    »
 
Zeitschriftentitel:
Mol Biol Cell 
Jahr:
2008 
Band / Volume:
19 
Heft / Issue:
10 
Seitenangaben Beitrag:
4434-41 
Sprache:
eng 
Print-ISSN:
1059-1524 
TUM Einrichtung:
r Pharmakologie und Toxikologie; r Dermatologie und Allergologie