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Dokumenttyp:
journal article 
Autor(en):
Schmidtko, A; Gao, W; Sausbier, M; Rauhmeier, I; Sausbier, U; Niederberger, E; Scholich, K; Huber, A; Neuhuber, W; Allescher, HD; Hofmann, F; Tegeder, I; Ruth, P; Geisslinger, G 
Titel:
Cysteine-rich protein 2, a novel downstream effector of cGMP/cGMP-dependent protein kinase I-mediated persistent inflammatory pain. 
Abstract:
The cGMP/cGMP-dependent protein kinase I (cGKI) signaling pathway plays an important role in spinal nociceptive processing. However, downstream targets of cGKI in this context have not been identified to date. Using a yeast two-hybrid screen, we isolated cysteine-rich protein 2 (CRP2) as a novel cGKI interactor in the spinal cord. CRP2 is expressed in laminas I and II of the mouse spinal cord and is colocalized with cGKI, calcitonin gene-related peptide, and isolectin B4. Moreover, the majority...    »
 
Zeitschriftentitel:
J Neurosci 
Jahr:
2008 
Band / Volume:
28 
Heft / Issue:
Seitenangaben Beitrag:
1320-30 
Sprache:
eng 
Print-ISSN:
0270-6474 
TUM Einrichtung:
r Pharmakologie und Toxikologie