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Dokumenttyp:
journal article 
Autor(en):
Hartmann, J; Dragicevic, E; Adelsberger, H; Henning, HA; Sumser, M; Abramowitz, J; Blum, R; Dietrich, A; Freichel, M; Flockerzi, V; Birnbaumer, L; Konnerth, A 
Titel:
TRPC3 channels are required for synaptic transmission and motor coordination. 
Abstract:
In the mammalian central nervous system, slow synaptic excitation involves the activation of metabotropic glutamate receptors (mGluRs). It has been proposed that C1-type transient receptor potential (TRPC1) channels underlie this synaptic excitation, but our analysis of TRPC1-deficient mice does not support this hypothesis. Here, we show unambiguously that it is TRPC3 that is needed for mGluR-dependent synaptic signaling in mouse cerebellar Purkinje cells. TRPC3 is the most abundantly expressed...    »
 
Zeitschriftentitel:
Neuron 
Jahr:
2008 
Band / Volume:
59 
Heft / Issue:
Seitenangaben Beitrag:
392-8 
Sprache:
eng 
Print-ISSN:
0896-6273 
TUM Einrichtung:
r Neurowissenschaften