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Dokumenttyp:
journal article 
Autor(en):
Korn, T; Mitsdoerffer, M; Croxford, AL; Awasthi, A; Dardalhon, VA; Galileos, G; Vollmar, P; Stritesky, GL; Kaplan, MH; Waisman, A; Kuchroo, VK; Oukka, M 
Titel:
IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells. 
Abstract:
The conditions leading to the induction of adaptive Foxp3(+) regulatory T cells (T-regs) from peripheral T cells in vivo are incompletely understood. Here, we show that unresponsiveness of T cells to IL-6 by T cell-selective deletion of gp130 or immunization of wild-type mice with antigen in incomplete Freund's adjuvant (IFA), which fails to induce IL-6, promotes the conversion of peripheral CD4(+) T cells into adaptive Foxp3(+) T-regs. Thus, both T cell-conditional gp130 knockout (KO) mice immu...    »
 
Zeitschriftentitel:
Proc Natl Acad Sci U S A 
Jahr:
2008 
Band / Volume:
105 
Heft / Issue:
47 
Seitenangaben Beitrag:
18460-5 
Sprache:
eng 
Print-ISSN:
0027-8424 
TUM Einrichtung:
Neurologische Klinik und Poliklinik